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Studies conducted with Caco-2 cells in a laboratory setting, utilizing inhibitors of transporter proteins and knockout methods, have pinpointed the main transporter proteins responsible for metformin as the organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), serotonin transporter (SERT), and high-affinity choline transporter (CHT) (Han et al., 2015)

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